JNKi- and DAC-programmed mesenchymal stem/stromal cells from hESCs facilitate hematopoiesis and alleviate hind limb ischemia.

Yimeng WeiHuixing HouLeisheng ZhangNianhuan ZhaoChengwen LiJiali HuoYing LiuWenxia ZhangZongjin LiDengke LiuZhibo HanLei ZhangBaoquan SongYing ChiZhongchao Han

Published in: Stem cell research & therapy (2019)

In the study, we established a high-efficient procedure for large-scale generation of MSCs from hESCs, which would be of great help for genesis and mechanism studies of MSCs. Meanwhile, the derived cells provide an alternative for translational clinical research.

Keyphrases

mesenchymal stem cells
bone marrow
induced apoptosis
umbilical cord
stem cells
cell cycle arrest
minimally invasive
cell proliferation
pi k akt