Serum biomarker panel diagnostics in pancreatic ductal adenocarcinoma: the clinical utility of soluble interleukins, IFN-γ, TNF-α and PD-1/PD-L1 in comparison to established serum tumor markers.
Klara DormanMiriam GerckensStephan KrugerKimberly KruegerZsuzsanna MayerAlexander RuppDanmei ZhangLena WeissC Benedikt WestphalenMichael HaasMichael GuentherSteffen OrmannsFrank KlawonnJens WernerMichael von Bergwelt-BaildonVolker HeinemannStefan BoeckStefan HoldenriederPublished in: Journal of cancer research and clinical oncology (2022)
IL-10 levels may have independent prognostic value in locally advanced PDAC, whereas CYFRA 21-1 levels are prognostic after PDAC surgery. CYFRA 21-1 and IL-8 have been identified to best discriminate metastatic from locally advanced patients.
Keyphrases
- locally advanced
- squamous cell carcinoma
- rectal cancer
- end stage renal disease
- neoadjuvant chemotherapy
- ejection fraction
- radiation therapy
- newly diagnosed
- chronic kidney disease
- minimally invasive
- small cell lung cancer
- rheumatoid arthritis
- phase ii study
- peritoneal dialysis
- prognostic factors
- dendritic cells
- immune response
- clinical trial
- coronary artery bypass
- lymph node
- percutaneous coronary intervention
- study protocol
- double blind