Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery.

Ilhame DibounManjunath RamanjaneyaYasser MajeedLina AhmedMohammed BashirAlexandra E ButlerAbdul Badi Abou-SamraStephen L AtkinNayef A MazloumMohamed A Elrayess

Published in: Journal of translational medicine (2020)

This study highlights the metabolite alterations in women in their second trimester with diabetes mellitus and identifies predictive indicators of pre-term delivery. Future studies to confirm these associations in other cohorts and investigate their functional relevance and potential utilization for targeted therapies are warranted.

Keyphrases

pregnancy outcomes
pregnant women
gestational age
preterm infants
genome wide
weight gain
birth weight
polycystic ovary syndrome
type diabetes
single cell
gene expression
dna methylation
physical activity
risk assessment
metabolic syndrome
weight loss
body mass index