Cancer cells, on your histone marks, get SETDB1, silence retrotransposons, and go!

Luisa Robbez-MassonChristopher H C TieHelen M Rowe

Published in: The Journal of cell biology (2017)

Cancer cells thrive on genetic and epigenetic changes that confer a selective advantage but also need strategies to avoid immune recognition. In this issue, Cuellar et al. (2017. J. Cell Biol https://doi.org/10.1083/jcb.201612160) find that the histone methyltransferase SETDB1 enables acute myeloid leukemia cells to evade sensing of retrotransposons by innate immune receptors.

Keyphrases

innate immune
dna methylation
acute myeloid leukemia
induced apoptosis
genome wide
cell cycle arrest
gene expression
single cell
cell therapy
allogeneic hematopoietic stem cell transplantation
copy number
signaling pathway
mesenchymal stem cells
cell proliferation