The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling.

Tsong-Hai LeePei-Shan LiuMing-Ming TsaiJiun-Liang ChenSu-Jane WangHsi-Lung Hsieh

Published in: Cell communication and signaling : CCS (2020)

These results demonstrated that a novel autocrine pathway for BK-induced MMP-9 protein expression is mediated through activation of STAT3 by native COX-2/PGE2-mediated c-Src/Jak2/ERK cascades in brain astrocytes. Video Abstract.

Keyphrases

cell proliferation
high glucose
diabetic rats
signaling pathway
drug induced
resting state
binding protein
long non coding rna
stress induced