Venous Thromboembolic Events in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia.
Sandra Renee JonesRoshni B PatelMahvish Q RahimSandra K AlthouseSandeep BatraPublished in: Journal of adolescent and young adult oncology (2022)
Acute venous thromboembolisms (VTEs) are serious complications that occur during acute lymphoblastic leukemia (ALL) chemotherapy. The data elucidating risk factors for developing VTEs are limited in adolescent and young adult patients being treated per pediatric ALL protocols. In a cohort of 66 patients, 14 (21%) experienced VTEs. The majority of VTEs occurred during induction chemotherapy after the first dose of asparaginase, and in the upper extremities. Five-year relapse-free and overall survival were not impacted by VTEs. Contrary to VTEs in adults, hypoalbuminemia and increased body mass index were not associated with an elevated risk of VTE.
Keyphrases
- acute lymphoblastic leukemia
- young adults
- body mass index
- end stage renal disease
- newly diagnosed
- allogeneic hematopoietic stem cell transplantation
- mental health
- childhood cancer
- ejection fraction
- locally advanced
- chronic kidney disease
- liver failure
- free survival
- peritoneal dialysis
- risk factors
- radiation therapy
- big data
- deep learning
- intensive care unit
- hepatitis b virus
- middle aged
- aortic dissection
- soft tissue
- chemotherapy induced
- artificial intelligence
- extracorporeal membrane oxygenation