Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil.

Alice Maria de Magalhães OrnelasCaroline Xavier-de-CarvalhoLucia Elena Alvarado-ArnezMarcelo Ribeiro-AlvesÁtila Duque RossiAmilcar TanuriRenato Santana de AguiarMilton Ozório MoraesCynthia Chester Cardoso

Published in: Memorias do Instituto Oswaldo Cruz (2019)

This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune response to DENV.

Keyphrases

dengue virus
zika virus
aedes aegypti
young adults
genome wide
gene expression
dna methylation