Sustained-Release Esketamine Based Nanoparticle-Hydrogel Delivery System for Neuropathic Pain Management.

Hao ZhangPing ZhouYi JiangLiu LiFei JuQuan ChengYou Lang ZhouYuan Zhou

Published in: International journal of nanomedicine (2023)

These results indicate that the sustained-release esketamine based on the nanoparticle-hydrogel delivery system can safely produce a lasting analgesic effect on SNL mice, and its mechanism might be related to modulating the activation of astrocytes in the spinal cord and inhibiting the excitability of neurons in DRG.

Keyphrases

neuropathic pain
spinal cord
drug delivery
spinal cord injury
signaling pathway
hyaluronic acid
iron oxide
tissue engineering
wound healing
high fat diet induced
transcranial direct current stimulation
type diabetes
insulin resistance
anti inflammatory
working memory
drug induced