In this report, we evaluated the relationships between genomic profiles (gene mutations and molecular signatures) of tumour samples from patients with metastatic prostate cancer and early death. We found that mutations of specific genes, notably TP53 and APC/CTNNB1 related to the Wnt pathway, are associated with visceral metastatic progression and an earlier age at death.
Keyphrases
- prostate cancer
- radical prostatectomy
- end stage renal disease
- insulin resistance
- ejection fraction
- genome wide
- chronic kidney disease
- newly diagnosed
- squamous cell carcinoma
- small cell lung cancer
- cell proliferation
- prognostic factors
- peritoneal dialysis
- type diabetes
- skeletal muscle
- dna methylation
- patient reported
- bioinformatics analysis