Analysis of infections among patients with historical culture positive for extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae : Is ESBL-targeted therapy always needed?
Tyler J StoneMichael E DeWittJames W JohnsonJames R BeardsleyIqra MunawarElizabeth L PalavecinoVera P LutherChristopher A OhlJohn C WilliamsonPublished in: Antimicrobial stewardship & healthcare epidemiology : ASHE (2023)
History of ESBL-producing EC/KP culture is associated with subsequent infection caused by ESBL-producing EC/KP, particularly within 180 days after the historical culture. Among patients presenting with infection and a history of ESBL-producing EC/KP, other factors should be considered in making empiric antibiotic decisions, and ESBL-targeted therapy may not always be warranted.