FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages.

Dongxue WangFei LiuLiyun ZhuPing LinFanyi HanXue WangXianxi TanLi LinYe Xiong

Published in: Journal of neuroinflammation (2020)

rhFGF21 treatment promoted functional recovery in experimental stroke by modulating microglia/macrophage-mediated neuroinflammation via the NF-κB and PPAR-γ signaling pathways, making it a potential anti-inflammatory agent for stroke treatment.

Keyphrases

signaling pathway
atrial fibrillation
lps induced
inflammatory response
traumatic brain injury
anti inflammatory
cerebral ischemia
lipopolysaccharide induced
pi k akt
cognitive impairment
type diabetes
risk assessment
induced apoptosis
smoking cessation