Epigenetic Regulation of Dental Pulp Stem Cell Fate.
Dan ZhouLu GanYiran PengYachuan ZhouXin ZhouMian WanYi FanXin XuXuedong ZhouLiwei ZhengWei DuPublished in: Stem cells international (2020)
Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs.
Keyphrases
- stem cells
- dna methylation
- gene expression
- cell fate
- mesenchymal stem cells
- induced apoptosis
- genome wide
- cell therapy
- endothelial cells
- circulating tumor
- palliative care
- working memory
- cell cycle arrest
- single molecule
- bone marrow
- umbilical cord
- cell free
- endoplasmic reticulum stress
- cell proliferation
- copy number
- oxidative stress
- case control
- signaling pathway
- cell death