Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization.
QuanQiu WangPamela B DavisXin QiShu G ChenMark E GurneyGeorge PerryP Murali DoraiswamyRong XuPublished in: Alzheimer's research & therapy (2021)
Our analysis produces a novel framework to offer insights into the mechanistic links between gut microbial metabolites, microglia, and AD, with the overall goal to facilitate disease mechanism understanding, therapeutic target identification, and designing confirmatory experimental studies.