IL13Rα2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases.

Ricaurte Alejandro Marquez-Ortiz Maria Jose Contreras-ZarateVesna TesicKaren L F Alvarez-ErasoGina KwakZachary LittrellJames C Costello Varsha SreekanthD Ryan OrmondSana D KaramPeter KabosDiana M Cittelly

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Non-genomic phenotypic adaptations at metastatic sites are critical to BM progression and patients' prognosis. This study opens the road to use IL13Rα2 targeting as a therapeutic strategy for BM.

Keyphrases

brain metastases
small cell lung cancer
end stage renal disease
ejection fraction
newly diagnosed
squamous cell carcinoma
signaling pathway
peritoneal dialysis
gene expression
copy number
high intensity
patient reported outcomes
cancer therapy