Stratification-Based Investigation of Adjunctive Brimonidine or Timolol to a Prostaglandin Analogue in Japanese Patients with Normal-Tension Glaucoma.
Keiji YoshikawaShiro MizoueKoji NittaHiroshi OnishiMasaharu IkedaAkemi MizunoKaori KawazoeYoshiyuki TamadaRyuji TakedaShun MatsumotoPublished in: Clinical ophthalmology (Auckland, N.Z.) (2021)
The IOP-lowering efficacy of Brim was non-inferior to that of Tim after stratification by baseline IOP (12 ≤ IOP ≤ 16 mmHg). The discrepancy in the IOP-lowering effects of Brim and Tim observed in the previous study was thought to be related to enrolled subjects with low baseline IOP. PR decreased significantly in the Tim group even after age stratification. PR should be considered when selecting β-blockers for glaucoma treatment.