Astragaloside IV Synergizing with Ferulic Acid Ameliorates Pulmonary Fibrosis by TGF-β1/Smad3 Signaling.
Jiahuan TongZhisong WuYuchen WangQingxun HaoHaoge LiuFang CaoYang JiaoPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
Astragaloside IV combined with ferulic acid regulated the oxidative stress of lung tissues and TGF-β1/Smad3 signaling through miR-29b, thereby reducing the degree of pulmonary fibrosis. This provides a reference direction for the clinical treatment of IPF patients.
Keyphrases
- pulmonary fibrosis
- transforming growth factor
- oxidative stress
- epithelial mesenchymal transition
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- gene expression
- peritoneal dialysis
- mouse model
- transcription factor
- signaling pathway
- diabetic rats
- combination therapy