Impact of Chronic Kidney Disease on Corneal Neuroimmune Features in Type 2 Diabetes.
Kofi AsieduMaria MarkoulliShyam Sunder TummanapalliJeremy Chung Bo ChiangSultan AlotaibiLeiao Leon WangRoshan DhanapalaratnamNatalie KwaiAnn PoyntenArun V KrishnanPublished in: Journal of clinical medicine (2022)
The study showed that central corneal dendritic cell density is increased in T2DM-CKD compared to T2DM-no CKD, with groups matched for peripheral neuropathy severity. This is accompanied by a loss of central corneal nerve fibers. The findings raise the possibility of additional local factors exacerbating central corneal nerve injury in people with diabetic chronic kidney disease.