Puerarin Attenuates Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress and Suppresses Inflammation by Modulating the JNK and IKKβ/NF-κB Pathways in Epididymal White Adipose Tissue of Mice on a High-Fat Diet.

Jie SunYan LiuJinjin ZhangHuilin ShiRujiao JiangMeihua GuoYilin LiuBo LiuNing WangRui MaDanna ZhangFang ZhangShujing WangYingjie Wu

Published in: Molecular nutrition & food research (2024)

These findings suggest that puerarin mitigates insulin resistance by inhibiting ER stress and suppressing inflammation through the JNK and IKKβ/NF-κB pathways. This highlights the promising clinical application of puerarin in the treatment of insulin resistance.

Keyphrases

signaling pathway
insulin resistance
high fat diet
induced apoptosis
adipose tissue
endoplasmic reticulum stress
high fat diet induced
pi k akt
oxidative stress
skeletal muscle
metabolic syndrome
polycystic ovary syndrome
type diabetes
glycemic control
cell death
combination therapy
radiation therapy