Palmitoylation of gasdermin D directs its membrane translocation and pore formation in pyroptosis.

Arumugam BalasubramanianLaxman GhimireAlan Y HsuHiroto KambaraXing LiuTomoya HasegawaRong XuMuhammad TahirHongbo YuAlan Y HsuHongbo R Luo

Published in: bioRxiv : the preprint server for biology (2023)

LPS-induced palmitoylation at Cys191/Cys192 is required for GSDMD membrane translocation and its pore-forming activity in macrophages.

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