High-content imaging analyses of γH2AX-foci and micronuclei in TK6 cells elucidated genotoxicity of chemicals and their clastogenic/aneugenic mode of action.

Akira TakeiriKaori MatsuzakiShigeki MotoyamaMariko YanoAsako HaradaChiaki KatohKenji TanakaMasayuki Mishima

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2019)

A HC imaging assay to detect γH2AX foci and MNi in TK6 cells was established, and the assay provided information on the aneugenic/clastogenic mode of action.

Keyphrases

induced apoptosis
cell cycle arrest
high resolution
high throughput
endoplasmic reticulum stress
cell death
health information
cell proliferation
photodynamic therapy