Hypoxia Attenuates Pressure Overload-Induced Heart Failure.
Natali FroeseMalgorzata SzaroszykPaolo GaluppoJoseph R ViskerChristopher WerleinMortimer Korf-KlingebielDominik BerlinerMarc R RebollRana HamoucheSimona GegelYong WangWinfried HofmannMing TangRobert GeffersAdam R WendeMark P KühnelDanny D JonigkGeorg HansmannKai C WollertE Dale AbelStavros G DrakosJohann BauersachsChristian RiehlePublished in: Journal of the American Heart Association (2024)
Hypoxia attenuates LVPO-induced heart failure. Cardioprotective pathways identified in the HxTAC model might also contribute to cardiac recovery following left ventricular assist device support. These data highlight the potential of our novel HxTAC model to identify hypoxia-mediated cardioprotective mechanisms and therapeutic targets that attenuate LVPO-induced heart failure and mediate cardiac recovery following mechanical circulatory support.