Effects of Monotherapy with Clopidogrel vs. Aspirin on Vascular Function and Hemostatic Measurements in Patients with Coronary Artery Disease: The Prospective, Crossover I-LOVE-MONO Trial.
Hyun Woong ParkMin-Gyu KangJong-Hwa AhnJae-Seok BaeUdaya S TantryPaul A GurbelYoung Hoon JeongPublished in: Journal of clinical medicine (2021)
In CAD patients, clopidogrel vs. aspirin monotherapy was associated with better endothelial function, greater platelet inhibition and lower coagulation activity, suggesting pleiotropic effects of clopidogrel on endothelial function and hemostatic profiles.
Keyphrases
- antiplatelet therapy
- acute coronary syndrome
- percutaneous coronary intervention
- open label
- low dose
- end stage renal disease
- coronary artery disease
- newly diagnosed
- ejection fraction
- combination therapy
- cardiovascular events
- chronic kidney disease
- clinical trial
- prognostic factors
- phase iii
- study protocol
- phase ii
- type diabetes
- double blind
- atrial fibrillation