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Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single-cell RNA sequencing.

Shiwei HeJunfeng WangYanlei HuangFanyang KongRan YangYong ZhanZifeng LiChunjing YeLingdu MengYankang RenYing ZhouGong ChenZhen ShenSong SunShan ZhengRui Dong
Published in: Clinical and translational medicine (2023)
This work identifies intestinal fibrosis and related regulators in aganglionic segments of HSCR; hence, anti-fibrotic therapy may be considered to prevent HSCR-associated enterocolitis (HAEC), relieve intestinal stricture and improve cell therapy.
Keyphrases
  • cell therapy
  • single cell
  • rna seq
  • stem cells
  • genome wide
  • systemic sclerosis
  • high throughput
  • transcription factor
  • idiopathic pulmonary fibrosis
  • gene expression
  • dna methylation
  • bone marrow
  • preterm infants