Genome-Wide Association Study of Obstructive Sleep Apnea and Objective Sleep-Related Traits Identifies Novel Risk Loci in Han Chinese Individuals.

Huajun XuFeng LiuZhiqiang LiXinyi LiYuenan LiuNiannian LiXiaoxu ZhangZhenfei GaoXiaoman ZhangYupu LiuJianyin ZouLili MengSuru LiuHuaming ZhuXulan TangHongmin WuKaiming SuBin ChenDongzhen YuHaibo YeHaoyan ChenHongliang YiJian GuanShan-Kai YinYongyong Shi

Published in: American journal of respiratory and critical care medicine (2022)

We identified several novel genome-wide significant loci associated with OSA and objective sleep-related traits. Our findings provide insight into the genetic architecture of OSA and suggest that SLC52A3 might be a therapeutic target, while riboflavin might be a therapeutic agent.

Keyphrases

genome wide
obstructive sleep apnea
genome wide association study
dna methylation
positive airway pressure
copy number
physical activity
sleep apnea
gene expression
drug induced