Identification of a novel HOOK3-FGFR1 fusion gene involved in activation of the NF-kappaB pathway.
Xuehong ZhangFurong WangFanzhi YanDan HuangHaina WangBeibei GaoYuan GaoZhijie HouJiacheng LouWeiling LiJin-Song YanPublished in: Cancer cell international (2022)
The HOOK3-FGFR1 fusion gene may contribute to the pathogenesis of MDS and activate the NF-kappaB pathway. These findings highlight a potential novel approach for combination therapy for FGFR1 rearrangement patients.