Cardiovascular safety of pimitespib in patients with advanced solid tumors: An open-label, nonrandomized, phase 1 study.
Katsuhiko NaokiSatoshi IgawaHaruki UojimaHideyasu TsumuraNorihiko SengokuMasato KarayamaAkihiko ShimomuraTohru OhtakeYutaka ShioAyumu HosokawaYoshito KomatsuYuji KumagaiPublished in: Cancer (2024)
Pimitespib is a new anticancer drug that is being used to treat cancer in the stomach or intestines (gastrointestinal stromal tumors). This study demonstrated that pimitespib had no marked effect on heart rhythm or negative effects on the heart or blood vessels and had promising anticancer effects in Japanese patients with advanced solid tumors who were unable to tolerate or benefit from standard treatment.