A post-irradiation-induced replication stress promotes RET proto-oncogene breakage.

Fabio HechtLaura ValerioCarlos Frederico Lima GonçalvesMarylin HarinquetRabii Ameziane El HassaniDenise P CarvalhoStephane KoundrioukoffJean-Charles CadoretCorinne Dupuy

Published in: European thyroid journal (2024)

The findings suggest that post-irradiation in the RET gene causes a breakage in the replication fork, which could potentially invade another genomic area, including CCDC6. As a result, this could greatly contribute to the high prevalence of chromosomal RET/PTC rearrangements seen in patients exposed to external radiation.

Keyphrases

end stage renal disease
copy number
chronic kidney disease
ejection fraction
newly diagnosed
peritoneal dialysis
genome wide
high glucose
dna methylation
patient reported outcomes
oxidative stress