Effectiveness and safety of methotrexate monotherapy in patients with Crohn's disease refractory to anti-TNF-α: results from the ENEIDA registry.

Francisco MesoneroJesús Castro-PoceiroJose M BenítezBlau CampsMarisa IborraAlicia López-GarcíaPaola TorresMaría EsteveJoan ToscaFederico BertolettiPedro AlmelaXavier Calvet CalvoIsabel VeraLuis BujandaFernando GomollónCristina RodríguezBeatriz AntolínDavid BusquetsAlejandro HernándezMontserrat RiveroDavid Monfort I MiquelAndrés Castaño-GarcíaFrancisco Javier García-Alonso Eugeni DomènechAntonio López-Sanrománnull null

Published in: Alimentary pharmacology & therapeutics (2021)

The benefits observed suggest methotrexate monotherapy could be a valid option in Crohn's disease patients with previous failure to anti-TNFα.

Keyphrases

rheumatoid arthritis
high dose
combination therapy
open label
low dose
clinical trial