Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes.

Yuanxin XiJiejun ShiWenqian LiKaori TanakaKendra L AlltonDana RichardsonJing LiHector L FrancoAnusha NagariVenkat S MalladiLuis Della ColettaMelissa S SimperKhandan KeyomarsiJianjun ShenMark T BedfordXiaobing ShiMichelle C BartonW Lee KrausWei LiSharon Y R Dent

Published in: BMC genomics (2018)

Together, these datasets provide a comprehensive resource for histone modification profiles that define epigenetic landscapes and reveal key chromatin signatures in breast cancer cell line subtypes with potential to identify novel and actionable targets for treatment.

Keyphrases

dna methylation
genome wide
gene expression
single cell
dna damage
transcription factor
rna seq
combination therapy
young adults
risk assessment