Overcoming the UCB HSCs -Derived NK cells Dysfunction through Harnessing RAS/MAPK, IGF-1R and TGF-β Signaling Pathways.

Alireza ShokouhifarGholamreza Anani SarabMahboubeh YazdanifarMohammad FereidouniMasoumeh NouriMarzieh Ebrahimi

Published in: Cancer cell international (2021)

The differentiation of ex vivo expanded CD34 + cells through manipulation of RAS/MAPK, IGF-1R and TGF-β signaling pathways is an efficient approach for generating functional NK cells that can be used for cancer immunotherapy.

Keyphrases

nk cells
pi k akt
signaling pathway
cell cycle arrest
induced apoptosis
transforming growth factor
epithelial mesenchymal transition
wild type
oxidative stress
cell proliferation
binding protein
endoplasmic reticulum stress
growth hormone
cell death