A pyrophosphate-activated nanochannel inspired by a TRP ion channel.
Fei ZhuGuanxing YangManivannan Kalavathi DhinakaranRui WangMiaomiao SongHaibing LiPublished in: Chemical communications (Cambridge, England) (2019)
A pyrophosphate (PPi) selectively activated potassium channel was constructed via introducing the isoniazid functionalized calix[4]arene (C4NP) into a biomimetic nanochannel. The activation mechanism is mainly due to the changing of the inner surface charge and wettability of the nanochannel caused by PPi binding.