A pyrophosphate-activated nanochannel inspired by a TRP ion channel.

Fei ZhuGuanxing YangManivannan Kalavathi DhinakaranRui WangMiaomiao SongHaibing Li

Published in: Chemical communications (Cambridge, England) (2019)

A pyrophosphate (PPi) selectively activated potassium channel was constructed via introducing the isoniazid functionalized calix[4]arene (C4NP) into a biomimetic nanochannel. The activation mechanism is mainly due to the changing of the inner surface charge and wettability of the nanochannel caused by PPi binding.

Keyphrases

protein protein
mycobacterium tuberculosis
wastewater treatment
quantum dots
small molecule
binding protein
molecularly imprinted
high resolution
tissue engineering