Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins.
Robert MitchellBen MellowsJonathan SheardManuela AntonioliOliver KretzDavid ChambersMarie-Theres ZeunerJames E TomkinsBernd DeneckeLuca MusanteBarbara JochFlorence Debacq-ChainiauxHarry HolthoferSteve RayTobias B HuberJoern DengjelPaolo De CoppiDarius WideraKetan PatelPublished in: Stem cell research & therapy (2019)
Taken together, our study implies that extracellular vesicles and soluble molecules within ADSC secretome act in a synergistic manner to promote muscle generation.