Construction of Vicinal Quaternary Carbon Centers via Cobalt-Catalyzed Asymmetric Reverse Prenylation.

Minghe SunJia-Feng ChenShufeng Chen Changkun Li

Published in: Organic letters (2019)

A highly enantioselective cobalt-catalyzed reverse prenylation of β-ketoester with tertiary allylic carbonate to construct vicinal all-carbon quaternary carbon centers has been developed. By using the cobalt/( S, S)Ph-BPE complex generated in situ with zinc reduction, excellent branched to linear selectivity (>20:1) and up to 92% ee have been obtained.

Keyphrases

reduced graphene oxide
room temperature
carbon nanotubes
metal organic framework
neural network
solid state