Analysis of gene expression profiles along the tonotopic map of mouse cochlea by cDNA microarrays.
Takashi SatoKatsumi DoiHiroshi HibinoTakeshi KuboPublished in: Acta oto-laryngologica. Supplementum (2009)
Of 20,289 probes tested, 64 genes were found to be expressed in the apical portion more than fivefold more abundantly than in the basal portion, and 77 genes were vice versa. Of interest, the genes of several functional proteins such as beta2- and gamma2-subunits of GABA(A) receptors dominated the basal part, indicating that these molecules may be involved in high-frequency tuning of the hair cells and/or ganglion neurons.
Keyphrases
- high frequency
- gene expression
- genome wide
- transcranial magnetic stimulation
- bioinformatics analysis
- genome wide identification
- induced apoptosis
- small molecule
- spinal cord
- genome wide analysis
- cell cycle arrest
- cell death
- endoplasmic reticulum stress
- living cells
- cell proliferation
- signaling pathway
- photodynamic therapy
- pi k akt