Renal denervation attenuates pressure overload-induced cardiac remodelling in rats with biphasic regulation of autophagy.

Autophagy was suppressed at the early stage but activated at the late stage of TAC-induced cardiac remodelling. RDN attenuated the pathological changes of TAC rats, accompanied by attenuation of the changes in autophagy. Thus, RDN ameliorated TAC-induced cardiac remodelling partially associated with biphasic modulation of autophagy.