Bioactive Chemical Constituents and Pharmacological Activities of Ponciri Fructus.
Gopal LamichhaneJitendra PandeyHari Prasad DevkotaPublished in: Molecules (Basel, Switzerland) (2022)
Ponciri Fructus is a crude drug obtained from the dried immature fruits of Poncirus trifoliata (L). Raf. (Syn. Citrus trifoliata L.). This study aims to compile and analyze the ethnomedicinal uses, bioactive constituents, and pharmacological activities of Ponciri Fructus. Various online bibliographic databases namely, SciFinder, PubMed, Google Scholar, and Web of Science were used for collecting information on traditional uses, biological activities, and bioactive constituents. Concerning ethnomedicinal uses, Ponciri Fructus is extensively used in traditional Korean, Chinese, and Kampo medicines to mitigate allergic reactions, inflammation, edema, digestive complications, respiratory problems, spleen-related problems, liver complications, neuronal pain, hyperlipidemia, rheumatoid arthritis, cardiovascular problems, hernia, sinusitis, and insomnia. Several studies have shown that Ponciri Fructus is a major source of diverse classes of bioactive compounds namely flavonoids, terpenoids, coumarins, phytosterols, and alkaloids. Several in vivo and in vitro pharmacological activity evaluations such as antidiabetic, anti-obesity, anti-inflammatory, antiallergic, antimelanogenic, gastroprotective, anticancer, and neuroprotective effects have been conducted from Ponciri Fructus. However, scientific investigations focusing on bioassay-guided isolation and identification of specific bioactive constituents are limited. Therefore, an in-depth scientific investigation of Ponciri Fructus focusing on bioassay-guided isolation, mechanism based pharmacological studies, pharmacokinetic studies, and evaluation of possible toxicities is necessary in the future.
Keyphrases
- mental health
- rheumatoid arthritis
- anti inflammatory
- public health
- metabolic syndrome
- case control
- chronic pain
- type diabetes
- risk factors
- optical coherence tomography
- social media
- pain management
- spinal cord injury
- health information
- machine learning
- disease activity
- emergency department
- weight gain
- ankylosing spondylitis
- systemic lupus erythematosus
- high fat diet
- neuropathic pain
- current status
- depressive symptoms
- systemic sclerosis
- allergic rhinitis