Germacrene A-A Central Intermediate in Sesquiterpene Biosynthesis.

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)

This review summarises known sesquiterpenes whose biosyntheses proceed through the intermediate germacrene A. First, the occurrence and biosynthesis of germacrene A in Nature and its peculiar chemistry will be highlighted, followed by a discussion of 6-6 and 5-7 bicyclic compounds and their more complex derivatives. For each compound the absolute configuration, if it is known, and the reasoning for its assignment is presented.

Keyphrases

cell wall
risk assessment
drug discovery