Tumor-derived exosomes induce immunosuppressive macrophages to foster intrahepatic cholangiocarcinoma progression.

Chubin LuoHaoyang XinZhengjun ZhouZhiqiang HuRongqi SunNa YaoQiman SunUyunbilig BorjiginXia WuJia FanXiaowu HuangShao-Lai Zhou Jian Zhou

Published in: Hepatology (Baltimore, Md.) (2022)

Tumor-derived exosomal miR-183-5p up-regulates PD-L1-expressing macrophages to foster immune suppression and disease progression in ICC through the miR-183-5p/PTEN/AKT/PD-L1 pathway. Exosomal miR-183-5p is a potential predictive biomarker for ICC progression and a potential target for development of therapeutic strategies against immune tolerance feature of ICC.

Keyphrases

cell proliferation
mesenchymal stem cells
machine learning
stem cells
signaling pathway
human health