In vitro and in vivo evaluation of [125/123I]-2-[4-(2-iodophenyl)piperidino]cyclopentanol([125/123I]-OI5V) as a potential sigma-1 receptor ligand for SPECT.

Taiki ShigenoTakashi KozakaYoji KitamuraKazuma OgawaJunichi TakiSeigo KinuyaKazuhiro Shiba

Published in: Annals of nuclear medicine (2021)

This study confirmed that [125/123I]OI5V selectively binds σ-1R in the rat brain in vivo. [123I]OI5V was suggested to be useful as a σ-1R ligand for SPECT.

Keyphrases

pet ct
human health