Population pharmacokinetics of intravenous cefotaxime indicates that higher doses are required for critically ill children.
Stan J F HartmanParth J UpadhyayRon A A MathôtMichiel van der FlierMichiel F SchreuderRoger J M BrüggemannCatherijne A J KnibbeSaskia N de WildtPublished in: The Journal of antimicrobial chemotherapy (2022)
Higher cefotaxime doses are required for adequate exposure for most pathogens in critically ill children. A higher dose frequency or continuous infusion is advisable to improve target attainment for intermediately susceptible pathogens.