Novel Th17 Lymphocyte Populations, Th17.1 and PD1+Th17, are Increased in Takayasu Arteritis, and Both Th17 and Th17.1 Sub-Populations Associate with Active Disease.
Kritika SinghUpendra RathoreMohit Kumar RaiManas Ranjan BeheraNeeraj JainManish OraDharmendra Singh BhadauriaSupriya SharmaGaurav PandeSanjay GambhirAlok NathSudeep KumarAman SharmaVikas AgarwalDurga Prasanna MisraPublished in: Journal of inflammation research (2022)
Novel Th17 sub-populations (Th17.1 and PD1+Th17) are elevated in TAK. Th17 lymphocytes associate with active TAK. In-vitro experiments on cultured PBMCs suggest promise for further evaluation of a combination of immunosuppressive tacrolimus with anti-fibrotic tadalafil (or other anti-fibrotic therapies) in clinical trials of TAK.