Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults.
Christian K DyeMichael J CorleyDongmei LiVedbar S KhadkaBrooks I MitchellRazvan SultanaAnnette Lum-JonesCecilia M ShikumaLishomwa C NdhlovuAlika K MaunakeaPublished in: Clinical epigenetics (2019)
Altogether, our data suggests a possible role for DNA methylation in regulating monocyte activity that may associate with the insulin-resistant phenotype. The methylomic landscape of insulin resistance in monocytes could originate from epigenetic dysregulation during HSC differentiation through the myeloid lineage. Understanding the factors involved with changes in the myeloid trajectory may provide further insight into the development of insulin resistance. Furthermore, regulation of specific genes that were implicated in our analysis reveal possible targets for modulating immune activity to ameliorate insulin resistance.
Keyphrases
- dna methylation
- genome wide
- dendritic cells
- insulin resistance
- hiv infected
- single cell
- type diabetes
- gene expression
- peripheral blood
- adipose tissue
- bone marrow
- metabolic syndrome
- high fat diet
- acute myeloid leukemia
- polycystic ovary syndrome
- glycemic control
- immune response
- skeletal muscle
- copy number
- antiretroviral therapy
- high fat diet induced
- cell free
- signaling pathway
- big data
- bioinformatics analysis
- artificial intelligence
- human health
- weight loss