Hypoxia-induced Tie1 drives stemness and cisplatin resistance in non-small cell lung carcinoma cells.

Chaojie LiNannan YangZhijin ChenNing XiaQungang ShanZiyin WangJian LuMingyi ShangZhongmin Wang

Published in: Cancer cell international (2021)

Our findings indicated that Tie1 is upregulated in a hypoxic environment by HIF-1α and contributes to tumorigenesis and cisplatin resistance through the promotion of stemness in NSCLC cells.

Keyphrases

stem cells
epithelial mesenchymal transition
induced apoptosis
small cell lung cancer
cell cycle arrest
cell therapy
endothelial cells
signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
pi k akt