New secondary metabolites produced by an engineered strain Streptomyces sp. XZQH13OEΔastC.

Two previously undescribed alkaloids ( 1-2 ), five known alkaloids ( 3-7 ) and five cyclodipeptides ( 8-12 ) were obtained from an ansatrienin-producing mutant strain Streptomyces sp. XZQH13OEΔ  astC . Their structures were elucidated by analysis of the 1D, 2D NMR and ESI HRMS data and by comparison with the reported data. The antibacterial activities of compounds 1-12 were evaluated.