Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol.

Erika K HardingIvana A SouzaMaria A GandiniVinícius M GadottiMd Yousof AliSun HuangFlavia T T AntunesTuan TrangGerald W. Zamponi

Published in: British journal of pharmacology (2023)

Our findings reveal differential modulation of Cav2.2 and Cav3.2 channels by CB1R and CBD. This advances our understanding of how different cannabinoids produce analgesia through action at different voltage-gated calcium channels and could influence the development of novel cannabinoid-based therapeutics for treatment of chronic pain.

Keyphrases

chronic pain
pain management
small molecule
genome wide
single cell
combination therapy
dna methylation