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Salt Sensitivity of Blood Pressure.

Jeremiah M AfolabiCheryl L LafferHeather K BeasleyAntentor O HintonSepiso K MasengaAnnet Kirabo
Published in: Circulation research (2024)
The year 2024 marks the centennial of the initiation of the American Heart Association. Over the past 100 years, the American Heart Association has led groundbreaking discoveries in cardiovascular disease including salt sensitivity of blood pressure, which has been studied since the mid-1900s. Salt sensitivity of blood pressure is an important risk factor for cardiovascular events, but the phenotype remains unclear because of insufficient understanding of the underlying mechanisms and lack of feasible diagnostic tools. In honor of this centennial, we commemorate the initial discovery of salt sensitivity of blood pressure and chronicle the subsequent scientific discoveries and efforts to mitigate salt-induced cardiovascular disease with American Heart Association leading the way. We also highlight determinants of the pathophysiology of salt sensitivity of blood pressure in humans and recent developments in diagnostic methods and future prospects.
Keyphrases
  • blood pressure
  • cardiovascular disease
  • cardiovascular events
  • hypertensive patients
  • heart rate
  • heart failure
  • type diabetes
  • blood glucose
  • current status
  • small molecule
  • drug induced
  • single cell
  • solid state