Melanoma cells with diverse invasive potential differentially induce the activation of normal human fibroblasts.
Justyna MazurkiewiczAleksandra SimiczyjewEwelina DratkiewiczKatarzyna Pietraszek-GremplewiczMichał MajkowskiMagdalena KotMarcin ZiętekRafał MatkowskiDorota NowakPublished in: Cell communication and signaling : CCS (2022)
Observed changes in CAFs' biology were mainly driven by highly aggressive melanoma cells (A375, WM9, Hs294T) compared to the less aggressive WM1341D cells and could promote melanoma invasion, as well as impact inflammation, angiogenesis, and acidification of the tumor niche. Interestingly, different approaches to CAFs acquisition seem to complement each other showing interactions between studied cells. Video Abstract.