PERK-STING-RIPK3 pathway facilitates cognitive impairment by inducing neuronal necroptosis in sepsis-associated encephalopathy.

Xiaofeng Guo You Wu Jia Qi Hongwei Ma Zhongmin Fan Shiquan Wang Lixia Du Yuliang Peng Zongping Fang Xijing Zhang

Published in: CNS neuroscience & therapeutics (2023)

PERK-STING-RIPK3 pathway facilitates cognitive impairment by inducing neuronal necroptosis in the pathology of SAE, which provided a new therapeutic target in SAE treatment.

Keyphrases

cognitive impairment
endoplasmic reticulum stress
endoplasmic reticulum
cerebral ischemia
intensive care unit
acute kidney injury
early onset
septic shock
brain injury
blood brain barrier