Primary epithelioid inflammatory myofibroblastic sarcoma of the brain with EML4::ALK fusion mimicking intra-axial glioma: a case report and brief literature review.
Eric Eunshik KimChul-Kee ParkKoung Mi KangYoonjin KwakSung-Hye ParkJae-Kyung WonPublished in: Journal of pathology and translational medicine (2024)
An aggressive subtype of inflammatory myofibroblastic tumor, epithelioid inflammatory myofibroblastic sarcoma occurs primarily inside the abdominal cavity, followed by a pulmonary localization. Most harbor anaplastic lymphoma kinase (ALK) gene rearrangements, with RANBP2 and RRBP1 among the well-documented fusion partners. We report the second case of primary epithelioid inflammatory myofibroblastic sarcoma of the brain, with a well-known EML4::ALK fusion. The case is notable for its intra-axial presentation that clinico-radiologically mimicked glioma.
Keyphrases
- oxidative stress
- advanced non small cell lung cancer
- resting state
- case report
- white matter
- pulmonary hypertension
- diffuse large b cell lymphoma
- dna methylation
- functional connectivity
- gene expression
- copy number
- cerebral ischemia
- tyrosine kinase
- hiv infected
- brain injury
- men who have sex with men
- hiv testing
- blood brain barrier