Whole blood mitochondrial copy number in clinical populations with mood disorders: a meta-analysis.

Cali A CalarcoSwarnapali M KeppetipolaGautam KumarAndrea Goldstein Shipper Mary Kay Lobo

Published in: bioRxiv : the preprint server for biology (2023)

Together our data suggest whole blood/leukocyte mtDNAcn may be a useful biomarker for mood disorders, with MDD and BD Type II associated with higher mtDNAcn, and BD Type I associated with lower mtDNAcn. Further study of blood mtDNAcn could predict downstream health outcomes or treatment responsivity in individuals with mood disorders.

Keyphrases

copy number
bipolar disorder
mitochondrial dna
sleep quality
major depressive disorder
genome wide
oxidative stress
dna methylation
electronic health record
depressive symptoms